After being relegated in 2024, Sassuolo bounced back immediately by winning promotion from Serie B. Their return to Serie A has been solid, with the team establishing itself as a stable mid-table side.

While St. Pauli are struggling to keep pace, Cologne appear slightly more stable in recent weeks, setting up a tightly contested matchup.

This matchup presents a contrast between a title-chasing side and a stable mid-table team with fluctuating form.

Cagliari, meanwhile, are battling to stay clear of the relegation zone, making this a clash between title ambition and survival urgency.

Las Palmas are pushing hard for a top-six finish and a playoff spot, while Leganes are trying to stabilize their season and potentially sneak into contention. The stakes, however, clearly favor the home side.

Blackburn are still fighting for survival, while Coventry are closing in on a Premier League return. Motivation, therefore, plays a crucial role in shaping expectations for this encounter.

Despite the aggregate advantage, Shakhtar’s away form and defensive focus will be tested against a Dutch side known for high-scoring home performances and aggressive attacking football.

Betis enter the return leg with stronger squad depth, home advantage, and more consistent European performances, while Braga arrive as dangerous underdogs capable of moments of brilliance but lacking stability in big away fixtures.

Bologna, meanwhile, arrive under pressure after a disappointing first-leg result and inconsistent European form. They will need something special to overturn the deficit against one of the most structured sides in the competition.